1-Deoxy-d-xylulose 5-phosphate is a biosynthetic intermediate in the non-mevalonate pathway.

Function

The enzyme involved in making 1-deoxy-d-xylulose 5-phosphate (DXP) is DXP synthase. The mechanism follows a catalysis of decarboxylative condensation of pyruvate and d-glyceraldehyde 3-phosphate to produce DXP. In addition, the molecule is involved in making thiamine (vitamin B1) and pyridoxol (vitamin B6).

The non-mevalonate pathway intermediate 1-deoxy-d-xylulose 5-phosphate (DXP) also acts as a precursor in making isoprenoids in many species such as bacteria, plants, and apicomplexan parasites, contributing to biological diversity.

See also

  • DXP reductoisomerase
  • Terpenoid

References


1DeoxyDxylulose 5phosphate as a common precursor of thiamin

(PDF) Overexpression of endogenous 1deoxydxylulose 5phosphate

Treatment wise 1deoxyDxylulose phosphate synthase and... Download

(PDF) Crystal Structure of 1DeoxyDxylulose5phosphate

Xylulose 5 Phosphate